Low cost optical detection of DNA hybridization on biochips
نویسندگان
چکیده
منابع مشابه
Optical fibre-based detection of DNA hybridization.
A dual-peak LPFG (long-period fibre grating), inscribed in an optical fibre, has been employed to sense DNA hybridization in real time, over a 1 h period. One strand of the DNA was immobilized on the fibre, while the other was free in solution. After hybridization, the fibre was stripped and repeated detection of hybridization was achieved, so demonstrating reusability of the device. Neither st...
متن کاملModeling of DNA hybridization kinetics for spatially resolved biochips.
The marriage of microfluidics with detection technologies that rely on highly selective nucleic acid hybridization will provide improvements in bioanalytical methods for purposes such as detection of pathogens or mutations and drug screening. The capability to deliver samples in a controlled manner across a two-dimensional hybridization detection platform represents a substantial technical chal...
متن کاملDNA Optical Detection Based on Porous Silicon Technology: from Biosensors to Biochips
A photochemical functionalization process which passivates the porous silicon surface of optical biosensors has been optimized as a function of the thickness and the porosity of the devices. The surface modification has been characterized by contact angle measurements. Fluorescence measurements have been used to investigate the stability of the DNA single strands bound to the nanostructured mat...
متن کاملInterface Layering Phenomena in Capacitance Detection of DNA with Biochips
Reliable DNA detection is of great importance for the development of the Lab-on-chip technology. The effort of the most recent projects on this field is to integrate all necessary operations, such as sample preparation (mixing, PCR amplification) together with the sensor user for DNA detection. Among the different ways to sense the DNA hybridization, fluorescence based detection has been favore...
متن کاملFault Tolerant DNA Computing Based on Digital Microfluidic Biochips
Historically, DNA molecules have been known as the building blocks of life, later on in 1994, Leonard Adelman introduced a technique to utilize DNA molecules for a new kind of computation. According to the massive parallelism, huge storage capacity and the ability of using the DNA molecules inside the living tissue, this type of computation is applied in many application areas such as me...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Laser Physics
سال: 2009
ISSN: 1054-660X,1555-6611
DOI: 10.1134/s1054660x09020182